发明名称 |
HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR |
摘要 |
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
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申请公布号 |
US2012003697(A1) |
申请公布日期 |
2012.01.05 |
申请号 |
US201113230081 |
申请日期 |
2011.09.12 |
申请人 |
STEVENS SEAN;HUANG TAMMY T.;MARTIN JOEL H.;FAIRHURST JEANETTE L.;RAFIQUE ASHIQUE;SMITH ERIC;POBURSKY KEVIN J.;PAPADOPOULOS NICHOLAS J.;FANDL JAMES P.;CHEN GANG;KAROW MARGARET;REGENERON PHARMACEUTICALS, INC. |
发明人 |
STEVENS SEAN;HUANG TAMMY T.;MARTIN JOEL H.;FAIRHURST JEANETTE L.;RAFIQUE ASHIQUE;SMITH ERIC;POBURSKY KEVIN J.;PAPADOPOULOS NICHOLAS J.;FANDL JAMES P.;CHEN GANG;KAROW MARGARET |
分类号 |
C12P21/00;C07H21/00;C12N1/21;C12N5/10;C12N15/63 |
主分类号 |
C12P21/00 |
代理机构 |
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