FUSION PROTEIN OF G-CSF VARIANT, PREPARATION METHOD AND USE THEREOF

摘要

The present invention provides a fusion protein for promoting the proliferation of granulocyte, which comprises a sequence of G-CSF variant/ carrier protein or carrier protein/ G-CSF variant. The G-CSF variant comprises one or more mutations selected from K34H, L35I, K40H and L41I. The fusion protein has longer half-life and better biological activity than natural G-CSF, and can be used to treat granulocytopenia. The present invention further provides a preparation method and use of the fusion protein.