THE SYNTHETIC DERIVATIVE OF DANSHEN COMPONENTS COMPRISING COMPOSITION INHIBITING AND PREVENTING OBESITY

摘要

PURPOSE: A composition containing Salvia miltiorrhiza Bunge derivatives is provided to reduce expressionof visfatin and resistin and to suppress inflammation. CONSTITUTION: A composition for preventing obesity contains 2-(3'-methoxy-4'-hydroxyphenyl)-6-(3-hydroxypropyl)-5-methoxybenzo[b]furan (5-methoxybenzofuran) which suppresses PPARgamma and C/EBP alpha expression. The compound is prepared by Wittig-Horner reaction, hydrogen reduction, LAH reduction, benzylation, Sonogashira coupling, iodine-induced cyclization, LAH reduction, and debenzylation from 2,5-dimethoxybenzaldehyde.