发明名称 |
Antibiotic 107891, its factors a1 and a2, pharmaceutically acceptable salts and compositions, und use thereof |
摘要 |
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M . catharralis, Neisseria species and H. influenzae and Mycobacteria. |
申请公布号 |
EP2402366(A1) |
申请公布日期 |
2012.01.04 |
申请号 |
EP20110001502 |
申请日期 |
2005.01.27 |
申请人 |
SENTINELLA PHARMACEUTICALS, INC. ("SENTINELLA") |
发明人 |
LAZZARINI, AMERIGA;GASTALDO, LUCIANO;CANDIANI, GIANPAOLO;CICILIATO, ISMAELA;LOSI, DANIELE;MARINELLI, FLAVIA;SELVA, ENRICO;PARENTI, FRANCO |
分类号 |
C07K14/195;A23K20/195;A61K38/12;A61K38/16;C07K7/64;C07K14/00;C12P1/06 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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