发明名称 |
PROTEIN TARGETS IN DISEASE |
摘要 |
<p>MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular disease, in particular congestive heart failure, is disclosed.</p> |
申请公布号 |
EP2401397(A2) |
申请公布日期 |
2012.01.04 |
申请号 |
EP20100705395 |
申请日期 |
2010.02.26 |
申请人 |
NATIONAL UNIVERSITY OF IRELAND, GALWAY |
发明人 |
SAMALI, AFSHIN;GUPTA, SANJEEV |
分类号 |
C12Q1/68;A61K31/7052;C12N15/113 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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