BIOACTIVE AGENT DELIVERY SYSTEM COMPRISING MODIFIED PULLULAN-POLYETHYLENEIMINE CONJUGATE AND METHOD FOR PRODUCING IT

摘要

PURPOSE: A bioactive substance delivery system containing cationic polymer conjugates is provided to stably maintain bond between the conjugate and genes. CONSTITUTION: A bioactive substance delivery system contains cationic polymer conjugates in which pullulan derivatives and polyethylene imine are conjugated. The pullulan derivative has a methyl group, bile acid, cholesterol, or non-ionic poly amino acid introduced to pullulan. A method for preparing the delivery system comprises: a step of acetylating the pullulan to synthesize a hydrophobic pullulan derivative; a step of polymerizing the hydrophobic pullulan derivative and a crosslinking agent; and a step of polymerizing the polymer and polyethylene imine. A gene therapeutic agent contains the delivery system as an active ingredient.