There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided tolerogenic peptides of myelin basic protein (MBP) selected by such a method and their use in a pharmaceutical composition and a method to treat and/or prevent multiple sclerosis.
申请公布号
CA2420949(C)
申请公布日期
2012.01.03
申请号
CA20012420949
申请日期
2001.08.17
申请人
APITOPE TECHNOLOGY (BRISTOL) LIMITED
发明人
WRAITH, DAVID CAMERON;ANDERTON, STEPHEN MARK;MAZZA, GRAZIELLA;PONSFORD, MARY;STREETER, HEATHER BARBARA