发明名称 |
HEPOXILIN ANALOG ENANTIOMERS |
摘要 |
The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.
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申请公布号 |
CA2643972(C) |
申请公布日期 |
2012.01.03 |
申请号 |
CA20072643972 |
申请日期 |
2007.04.19 |
申请人 |
PACE-ASCIAK, CECIL R. |
发明人 |
DEMIN, PETER;SORENSEN, ALEXANDRA SANTANA;MEYER, JEAN-PHILIPPE;PACE-ASCIAK, CECIL R. |
分类号 |
C07C69/732;A61K31/215;A61K31/336;A61P35/00;C07C67/48;C07C303/38 |
主分类号 |
C07C69/732 |
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地址 |
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