STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF

摘要

The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7--bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the A polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph A form of N-(3--ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.