发明名称 |
VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY |
摘要 |
The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed. |
申请公布号 |
EP2324113(A4) |
申请公布日期 |
2012.01.04 |
申请号 |
EP20090805653 |
申请日期 |
2009.08.10 |
申请人 |
LIGOCYTE PHARMACEUTICALS, INC. |
发明人 |
RICHARDSON, CHARLES;BARGATZE, ROBERT;HAYNES, JOEL;STEADMAN, BRYAN |
分类号 |
C12N7/01;A61K39/12;C07H21/00;C07K14/00;C07K14/08 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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