PHARMACEUTICAL COMPOSITIONS HAVING IMPROVED SOLUBILITY OF POORLY SOLUBLE TRICYCLIC DERIVATIVE COMPOUNDS

摘要

PURPOSE: A pharmaceutical composition with improved solubility of tricyclic derivative compounds is provided to enable solubilizing and to ensure long-term stability. CONSTITUTION: A pharmaceutical composition with improved solubility of tricyclic derivative compounds contains lipid mixture containing phospholipid, cholesterol, or ionic lipid; and lipid nanoparticles of containing insoluble tricyclic derivative compounds of chemical formula 1. The phospholipid is hydrogenated soybean phospatidylcholine(HSPC). The ionic lipid is dipalmitoyl phosphatidic acid(DPPA).