| 摘要 |
AN IMMUNOGENIC COMPOSITION HAVING 13 DISTINCT POLYSACCHARIDE-PROTEIN CONJUGATES AND OPTIONALLY. AN ALUMINUM-BASED ADJUVANT, IS DESCRIBED.EACH CONJUGATE CONTAINS A CAPSULAR POLYSACCHARIDE PREPARED FROM A DIFFERENT SEROTYPE OF STREPTOCOCCUS PNEUMONIAE (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F AND 23F) CONJUGATED TO A CARRIER PROTEIN. THE IMMUNOGENIC COMPOSITION, FORMULATED AS A VACCINE, INCREASES COVERAGE AGAINST PNEUMOCOCCAL DISEASE IN INFANTS AND YOUNG CHILDREN GLOBALLY, AND PROVIDES COVERAGE FOR SEROTYPES 6A AND 19A THAT IS NOT DEPENDENT ON THE LIMITATIONS OF SEROGROUP CROSS-PROLECLION. |
