HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING

摘要

HUNIAN ANTIBODIES THAT BIND HUMAN IL-12 AND INIETHODS FOR PRODUCING HUMAN ANTIBODIES, PREFERABLY RECOMBINANT HUMAN ANTIBODIES. THAT SPECIFICALLY BINDTOHUMANINTERIEUKIN-12(H]L-]'-))AREDISCLOSED. PREFER-REDANTIBODICSHAVEHIAH AFFINI@)RFORH[L-]2ANDNEUTRALIZELI[L-12ACTIVITI,I@?I,I[TOANCII?II,II?O. ANANUIBODYOFIHE IRIVEMION CAN BE A FULL-LENQTH ANTIBODY OR AN ANTIGEN-BINDING PORTION THEREOF. THE 5 ANTIBODIES, OR ANTIBODY PORTIONS, OFFFIE INVENTION ARE USEFUL FOR DETECTING HIL-12 AND FOR INHIBITING HIL-12 ACTIITV E.A.. IN A HUMAN SUBJECT SUFFERING FROM A DISORDER IN @OLICH HIL-12ACTIVITYISDETRIMENTAL. NTICLEICACIDS,VECTORSAJIDHOSICELLSFOREXPRESSINOIHE RECOMBINANT HUMAN ANTIBODIES OF THE INVENTION. AND METHODS OF SVNIHESIZINO THE RECOMBINANT HUMAN ANTIBODIES, ARE ALSO ENCOMPASSED BY THE INVENTION. 1.0 -3