发明名称 |
TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS |
摘要 |
The invention is directed to triazolopyridazine compounds of Formula (I): where R, R, R, R, R, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders. |
申请公布号 |
EA015754(B1) |
申请公布日期 |
2011.12.30 |
申请号 |
EA20080070085 |
申请日期 |
2006.12.18 |
申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
LU TIANBAO;ALEXANDER RICHARD;CONNORS RICHARD, W.;CUMMINGS MAXWELL, D.;GALEMMO ROBERT, A.;HUFNAGEL HEATHER, RAE;JOHNSON DANA, L.;KHALIL EHAB;LEONARD KRISTI, A.;MARKOTAN THOMAS, P.;MARONEY ANNA, C.;SECHLER JAN, L.;TRAVIS JEREMY, M.;TUMAN ROBERT, W. |
分类号 |
C07D487/04;A61K31/5025;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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