| 摘要 |
A method is described for determining a predisposition of an organism for Crohn's Disease, especially Crohn's Disease of the small intestine. In this context, in a biological specimen of an organism, the presence or the absence of SNP's in at least one gene is determined, which codes for a protein associated with the Writ signaling pathway in Paneth cells. The gene, in this instance, may be selected from TCF4, LRP5, LRP6, GSK3A, GSK3B and TCF7. The present methods and systems also relate to primers and allele-specific probes to prove the presence or the absence of an SNP, diagnostic kits which have at least one such primer or one such allele-specific probe, as well as the use of certain SNP's for determining a predisposition of an organism for Crohn's Disease. The present method and systems also relate to a method for the differential diagnosis of inflammatory bowel diseases, for distinguishing Crohn's Disease and the other respective inflammatory or infectious intestinal diseases.
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