摘要 |
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
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申请人 |
ARASAPPAN ASHOK;NJOROGE F. GEORGE;KWONG CECIL D.;ANANTHAN SUBRAMANIAM;BENNETT FRANK;CLARK JEREMY;KEZAR, III HOLLIS S.;GIRIJAVALLABHAN VINAY M.;HUANG YUHUA;HUELGAS REGINA;MADDRY JOSEPH A.;PIWINSKI JOHN J.;REYNOLDS ROBERT C.;ROYCHOWDHURY ABHIJIT;FOWLER ANITA T.;GENG FENG;SECRIST, III JOHN A.;SHIH NENG-YANG;VERMA VISHAL;VELAZQUEZ FRANCISCO;VENKATRAMAN SRIKANTH |
发明人 |
ARASAPPAN ASHOK;NJOROGE F. GEORGE;KWONG CECIL D.;ANANTHAN SUBRAMANIAM;BENNETT FRANK;CLARK JEREMY;KEZAR, III HOLLIS S.;GIRIJAVALLABHAN VINAY M.;HUANG YUHUA;HUELGAS REGINA;MADDRY JOSEPH A.;PIWINSKI JOHN J.;REYNOLDS ROBERT C.;ROYCHOWDHURY ABHIJIT;FOWLER ANITA T.;GENG FENG;SECRIST, III JOHN A.;SHIH NENG-YANG;VERMA VISHAL;VELAZQUEZ FRANCISCO;VENKATRAMAN SRIKANTH |