Described herein are recombinant rabies viruses encoding rabies virus glycoprotein and at least one heterologous glycoprotein from another lyssavirus, such as Mokola virus, Lagos bat virus and/or West Caucasian bat virus. In particular embodiments, the recombinant rabies virus includes two or three heterologous lyssavirus glycoproteins. The disclosed recombinant rabies viruses can be used as pan-lyssavirus vaccines to provide protection against lyssaviruses that cause rabies.
申请公布号
WO2011163446(A2)
申请公布日期
2011.12.29
申请号
WO2011US41579
申请日期
2011.06.23
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE;WU, XIANFU;RUPPRECHT, CHARLES, E.;KUZMIN, IVAN, V.
发明人
WU, XIANFU;RUPPRECHT, CHARLES, E.;KUZMIN, IVAN, V.