发明名称 |
Dominant Negative WNT2 Compositions and Methods of Use |
摘要 |
The present disclosure provides compositions, pharmaceutical preparations, kits and methods for inhibiting cell proliferation by contacting a cell expressing Fzd8 with a truncated Wnt2 polypeptide which acts as a dominant negative inhibitor of Fzd8 signaling. The present disclosure provides compositions, kits and methods for the detection of cancer by determining the level of Fzd8 and/or Wnt2 expression in a cell. |
申请公布号 |
US2011319337(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US200913142055 |
申请日期 |
2009.12.30 |
申请人 |
BRAVO DAWN;YOU LIANG;XU ZHIDONG;HE BIAO;JABLONS DAVID M. |
发明人 |
BRAVO DAWN;YOU LIANG;XU ZHIDONG;HE BIAO;JABLONS DAVID M. |
分类号 |
A61K38/17;A61P35/00;C07K14/47;C07K19/00;C12N1/19;C12N1/21;C12N5/09;C12N5/10;C12N15/12;C12N15/63;C12Q1/68;G01N33/566 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|