发明名称 |
GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE |
摘要 |
<p>Provided herein are nucleic acid sequences and polypeptides encoding a genetically encoded calcium indicator (GECI). Also provided are vectors and cells comprising the nucleic acid sequences and/or polypeptides. Kits comprising the nucleic acid sequences, polypeptides, vectors, cells and combinations thereof are also provided. Also provided herein are methods of screening for G-protein coupled receptor (GPCR) agonists and antagonists and methods of monitoring neural activity using the GECIs.</p> |
申请公布号 |
WO2011056975(A4) |
申请公布日期 |
2011.12.29 |
申请号 |
WO2010US55451 |
申请日期 |
2010.11.04 |
申请人 |
HOWARD HUGHES MEDICAL INSTITUTE;LOOGER, LOREN, LEE;TIAN, LIN |
发明人 |
LOOGER, LOREN, LEE;TIAN, LIN |
分类号 |
C12N15/12;C07K14/705;C12Q1/68;G01N33/68 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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