MACROCYCLIC TETRAPYRROLIC COMPOUND OF THE FAMILY OF PORPHYRINS, CHLORINS AND BACTERIOCHLORINS AS PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY

摘要

The present invention relates to macrocyclic tetrapyrrolic compounds of the family of porphyrins, chlorins and bacteriochlorins, having substitution in positions 5 and 15 of the porphyrin macrocycle with two phenyl groups having bromine, or chlorine atoms in the ortho position and a hydroxyl group in the meta position of the phenyl ring; and wherein positions 2, 3, 7, 8, 12, 13, 17 and/or 18 of the macrocycle are substituted with hydrogen or halogen atoms or alkyl, vinyl, carboxy, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylaryl, acetoxy or hydroxyalkyl groups. The compounds of this invention proved to be useful in PDT against human cancer cells.