发明名称 |
ENGINEERED BOTULINUM NEUROTOXIN C1 WITH SELECTIVE SUBSTRATE SPECIFICITY |
摘要 |
An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
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申请公布号 |
US2011318385(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US201113167156 |
申请日期 |
2011.06.23 |
申请人 |
JACKSON MEYER B.;WANG DONGSHENG;WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
JACKSON MEYER B.;WANG DONGSHENG |
分类号 |
A61K39/08;C07H21/04;C07K14/33;C12Q1/02 |
主分类号 |
A61K39/08 |
代理机构 |
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地址 |
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