Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.
申请公布号
WO2011163198(A2)
申请公布日期
2011.12.29
申请号
WO2011US41208
申请日期
2011.06.21
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;MEHTA, KAPIL;KUMAR, ANUPAM;FOK, JANSINA;ZHANG, SHUXING