CHIMERIC VIRUSES PRESENTING NON-NATIVE SURFACE PROTEINS AND USES THEREOF

摘要

CHIMERIC VIRUSES PRESENTING NON-NATIVE SURFACE PROTEINS AND USES THEREOFAbstractthe present invention provides numeric negative-stand RNA viruses that allows subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the. invention. In particular, the present invention provides chimeric influenza viruses engineered to express and incorporate into their onions a fusion protein comprising an ectodomain of a protein of an infectious agent and dm transmembrane and cytoplasmic domain of au influenza virus protein. Such chiimeric viruses induce an immune response against influenza virus and the infectious agent the present invention also provides chimeric Newcastle Disease viruses (NDV) engineered to express and incorporate into their virions a fusion protein comprising the ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response against NDV and the infectious agent.Figure I