发明名称 |
TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER |
摘要 |
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
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申请公布号 |
US2011318334(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US20100859990 |
申请日期 |
2010.08.20 |
申请人 |
MCCHESNEY JAMES D.;TAPOLSKY GILLES;EMERSON DAVID L.;MARSHALL JOHN;AHMED TAUSEEF;COHN ALLEN;KURMAN MICHAEL;MODIANO MANUEL;TAPESTRY PHARMACEUTICALS, INC. |
发明人 |
MCCHESNEY JAMES D.;TAPOLSKY GILLES;EMERSON DAVID L.;MARSHALL JOHN;AHMED TAUSEEF;COHN ALLEN;KURMAN MICHAEL;MODIANO MANUEL |
分类号 |
A61K31/357;A61K31/4188;A61K39/395;A61P35/00;C07D493/04 |
主分类号 |
A61K31/357 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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