发明名称 |
MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL |
摘要 |
The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA. |
申请公布号 |
US2011318787(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US201013145873 |
申请日期 |
2010.01.26 |
申请人 |
LESNIK OBERSTEIN SASKIA ANNE-MARIE JENNY;VAN OMMEN GARRIT-JAN BOUDEWIJN;RUS ADRIANA MARIE;DAUWERSE JOHANNES GREGORIUS;ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC |
发明人 |
LESNIK OBERSTEIN SASKIA ANNE-MARIE JENNY;VAN OMMEN GARRIT-JAN BOUDEWIJN;RUS ADRIANA MARIE;DAUWERSE JOHANNES GREGORIUS |
分类号 |
C12P19/34;C07H21/00;C07K14/415;C12N5/071 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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