发明名称 |
COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS |
摘要 |
<p>The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.</p> |
申请公布号 |
TN2010000398(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
TN20100000398 |
申请日期 |
2010.08.27 |
申请人 |
IRM LLC;NOVARTIS AG |
发明人 |
WU TOM YAO HSIANG;LI YONGKAI;CORTEZ ALEX;ZOU YEFEN;MISHRA PRANAB;ZHANG XIAOYUE;SKIBINSKI DAVID;SINGH MANMOHAN;VALIANTE NICHOLAS |
分类号 |
A61K31/4375;A61P37/04;C07D471/04;C07D471/12;C07D491/056;C07D491/12;C07D495/04 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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