发明名称 |
ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS |
摘要 |
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor. |
申请公布号 |
US2011319612(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US201113229422 |
申请日期 |
2011.09.09 |
申请人 |
GOLDMAKHER VIKTOR S.;LUTZ ROBERT J.;CHARI RAVI V.J.;KOVTUN YELENA V.;LAMBERT JOHN M.;STEEVES RITA;ERICKSON HANS K.;IMMUNOGEN INC. |
发明人 |
GOLDMAKHER VIKTOR S.;LUTZ ROBERT J.;CHARI RAVI V.J.;KOVTUN YELENA V.;LAMBERT JOHN M.;STEEVES RITA;ERICKSON HANS K. |
分类号 |
C07D498/12 |
主分类号 |
C07D498/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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