AN EXPRESSION SYSTEM OF GENES FOR TREATING ISCHEMIA USING AN OXYGEN DEPENDENT DEGRADATION DOMAIN OF ACTIVATING TRANSCRIPTION FACTOR-4

摘要

PURPOSE: An expression system of an ischemia therapeutic gene is provided to expression oxygen dependent degradation domain(ODD domain) sequence of ATF-4. CONSTITUTION: A recombinant expression vector contains a ischemia therapeutic gene and an oxygen dependent degradation domain(ODD domain) of ATF-4(activating transcription factor-4). The ischemia therapeutic gene is a vascularization factor. The ATF-4 ODDD sequence is derived from human and contains a base sequence of sequence number 1.