| 发明名称 |
MACROCYCLIC HEPATITIS C VIRUS INIHBITORS |
| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention describes novel macrocyclic compounds of formulae pharmaceutically acceptable salts or stereoisomers thereof, where R1 = -OR5, -NH-SO2R6; R2 = hydrogen; R3 = C1-6-alkyl; R4 = isoquinolinyl, possibly substituted; n equals 4 or 5; R5 = hydrogen; R6 = C3-7-cycloalkyl, and a pharmaceutical composition containing said compounds. ^ EFFECT: novel compounds have hepatitis C virus replication inhibitory action and can be used in medicine. ^ 6 cl, 32 ex, 1 tbl |
| 申请公布号 |
RU2437886(C2) |
申请公布日期 |
2011.12.27 |
| 申请号 |
RU20080107727 |
申请日期 |
2006.07.28 |
| 申请人 |
TIBOTEK FARMAS'JUTIKALZ LTD.;MEDIVIR AB |
发明人 |
RABUASSON P'ER ZHAN-MARI BERNAR;DE KOK KHERMAN AUGUSTINUS;DORANZH ISMET;VENDEVILL' SANDRIN MARI EHLEN;SJURLERO DOMINIK LUI NESTOR GILEHJN;TAKHRI ABDELLAKH;SIMONNE IVAN;VAN DE FREJKEN VIM;KHU LILI;SIMMEN KENNET ALAN;NIL'SSON KARL MAGNUS;SAMUEHL'SSON BENGT BERTIL;ROSENKVIST OSA ANNIKA KRISTINA;VALL'BERG KHANS KRISTIAN |
| 分类号 |
A61K31/4725;A61P31/14;C07D401/14;C07D487/04 |
主分类号 |
A61K31/4725 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
