发明名称 |
Process for preparing nebivolol |
摘要 |
The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (−)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol. |
申请公布号 |
US8084629(B2) |
申请公布日期 |
2011.12.27 |
申请号 |
US20090935150 |
申请日期 |
2009.03.16 |
申请人 |
VOLPICELLI RAFFAELLA;MARAGNI PAOLO;MASSACCESI FRANCO;MUNARI ILARIA;COTARCA LIVIUS;FOLETTO JOHNNY;ZACH SYSTEM S.P.A. |
发明人 |
VOLPICELLI RAFFAELLA;MARAGNI PAOLO;MASSACCESI FRANCO;MUNARI ILARIA;COTARCA LIVIUS;FOLETTO JOHNNY |
分类号 |
C07D407/04;C07D311/14 |
主分类号 |
C07D407/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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