发明名称 |
Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides |
摘要 |
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors. |
申请公布号 |
US8084471(B2) |
申请公布日期 |
2011.12.27 |
申请号 |
US20070226369 |
申请日期 |
2007.09.04 |
申请人 |
HAMILTON ANDREW;BECERRIL JORGE;YALE UNIVERSITY |
发明人 |
HAMILTON ANDREW;BECERRIL JORGE |
分类号 |
A01N43/40;A61K31/44;C07D213/22 |
主分类号 |
A01N43/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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