| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. <P>SOLUTION: The method comprises a step of: administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of general formula: A<SB POS="POST">b</SB>-X, where the group A<SB POS="POST">b</SB>comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis. <P>COPYRIGHT: (C)2012,JPO&INPIT |
