发明名称 |
HDL Particles for Delivery of Nucleic Acids |
摘要 |
Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
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申请公布号 |
US2011312899(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
US200913129349 |
申请日期 |
2009.11.17 |
申请人 |
SOOD ANIL K.;LACKO ANDRAS G.;LOPEZ-BERESTEIN GABRIEL;MANGALA LINGEGOWDA S.;MCCONATHY WALTER J.;PROKAI LASZLO;NAIR MAYA P.;UNT HEALTH SCIENCE CENTER AT FORT WORTH;BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SOOD ANIL K.;LACKO ANDRAS G.;LOPEZ-BERESTEIN GABRIEL;MANGALA LINGEGOWDA S.;MCCONATHY WALTER J.;PROKAI LASZLO;NAIR MAYA P. |
分类号 |
A61K38/17;A61P35/00;A61P35/04;B82Y5/00;C07K14/775;C12N5/071 |
主分类号 |
A61K38/17 |
代理机构 |
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主权项 |
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地址 |
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