发明名称 |
DNA POLYMERASES WITH INCREASESED 3'-MISMATCH DISCRIMINATION |
摘要 |
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. |
申请公布号 |
WO2011157438(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011EP03004 |
申请日期 |
2011.06.17 |
申请人 |
ROCHE DIAGNOSTICS GMBH;F. HOFFMANN-LA ROCHE AG |
发明人 |
REICHERT, FRED;BAUER, KEITH;MYERS, THOMAS, W. |
分类号 |
C12N9/12;C12N15/10;C12N15/54 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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