IKK-Beta SERINE-THREONINE PROTEIN KINASE INHIBITORS

摘要

Disclosed is a compound of formula (IA) or (IB), or a salt, N-oxide, hydrate or solvate thereof e.g. Cyclopentyl N-{ 4-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl} -L-leucinate, wherein R7 and Z are defined in the specification for the treatment of rheumatoid arthritis, psoriasis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, chronic obstructive pulmonary disease, asthma, multiple sclerosis, diabetes, atopic dermatitis, graft versus host disease, or systemic lupus erythematosus.