发明名称 |
MICROFLUIDIC DEVICE FOR GENETIC AND MITOCHONDRIAL ANALYSIS OF A BIOLOGICAL SAMPLE |
摘要 |
<p>A microfluidic device for analysis of genetic DNA and mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria has a mitochondrial membrane containing mitochondrial DNA and the nuclei have a nuclear membrane containing nuclear DNA, a first lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, a second lysis section for lysing the nuclear membrane, mitochondrial probes downstream of the first lysis section for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, nuclear probes downstream of the second lysis second for hybridization with target nucleic acid sequences in the nuclear DNA to form probe-target hybrids.</p> |
申请公布号 |
WO2011156847(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011AU00670 |
申请日期 |
2011.06.01 |
申请人 |
GENEASYS PTY LTD;SILVERBROOK, KIA;AZIMI, MEHDI |
发明人 |
SILVERBROOK, KIA;AZIMI, MEHDI |
分类号 |
B81B7/02;C12Q1/00;G01N33/50 |
主分类号 |
B81B7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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