| 摘要 |
Disclosed is a medical plaster for releasing the antiphlogistically active compound etofenamate to the skin, wherein this plaster has a structure comprising the top layer (a), the backing layer (c), the peelable protective layer (d) and optionally an intermediate layer (b), wherein: the top layer (a) comprises an inert material; the backing layer (c) comprises a self-adhesive polysiloxane as a backing material in which the antiphlogistically active compound, optionally together with an agent which promotes permeation through the skin and optionally further additives, is embedded in the form of a dispersion, wherein the adhesive strength of the backing layer (c) is in the range of from 0.8 N/25 mm to 1.4 N/25 mm; the backing layer (c) contains the active compound in a concentration in the range of from 1.0 wt. percent to 25.0 wt. percent, calculated for the total weight of the backing layer (c); the backing layer (c) contains the active compound in dispersed form with an average droplet size in the range of from 0.1 micron to 500 micron; the backing layer (c) adheres directly to the top layer (a) or is optionally joined to this via the intermediate layer (b); and the peelable protective layer (d) comprises an inert material, adheres to the backing layer (c) and can easily be peeled off from this. Etofenamate is also known as 2-(2-hydroxyethoxy)-ethyl (alpha, alpha, alpha-trifluoro-m-tolyl)anthranilate.
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