发明名称 |
USE WITH UTILIZATION OF SOLUBLE KLOTHO-, FGF23- AND FGFR-COMPLEX FORMATION MECHANISM IN CALCIFIED TISSUE |
摘要 |
<p>Provided are a method for screening an agent for controlling calcification, to which signal transduction relates, common to hard tissue and/or blood vessel; a calcification controlling agent; a method for examining calcification of a bone, calcification of a blood vessel and the pathological advance of a disease accompanying the same; and an examination kit therefor. The method for screening an agent for controlling calcification of hard tissue and/or blood vessel according to the first aspect comprises a step for, in a specimen in the absence and presence of a test compound, contacting soluble Klotho with FGFR and FGF23, and a step for selecting a compound causing a change in the specific signal transduction. The calcification controlling agent according to the second aspect comprises a compound capable of inhibiting or promoting the formation of a soluble Klotho-containing complex. The method for examining calcification according to the third aspect comprises a step for measuring the concentration of soluble Klotho, etc. The kit for examining calcification according to the fourth aspect contains a ligand having binding affinity to soluble Klotho, etc.</p> |
申请公布号 |
WO2011158655(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011JP62639 |
申请日期 |
2011.06.01 |
申请人 |
HIROSHIMA UNIVERSITY;YOSHIKO YUJI;MINAMIZAKI TOMOKO;YOSHIOKA HIROTAKA;MAEDA NORIHIKO;KOZAI KATSUYUKI;WATANABE KAZUAKI |
发明人 |
YOSHIKO YUJI;MINAMIZAKI TOMOKO;YOSHIOKA HIROTAKA;MAEDA NORIHIKO;KOZAI KATSUYUKI;WATANABE KAZUAKI |
分类号 |
G01N33/50;A61K31/7088;A61K39/395;A61K45/00;A61P9/00;A61P19/08;A61P19/10;C12N15/09;C12Q1/02;C12Q1/68;G01N33/15;G01N33/566;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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