发明名称 |
CYCLIC INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
摘要 |
This invention relates to novel compounds of the Formula Formulas (I), (Ia1-20), (Ib1-20), (Ic1-20), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell. |
申请公布号 |
US2011312950(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
US201013147454 |
申请日期 |
2010.02.03 |
申请人 |
ECKHARDT MATTHIAS;HIMMELSBACH FRANK;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
ECKHARDT MATTHIAS;HIMMELSBACH FRANK |
分类号 |
A61K31/5355;A61P1/16;A61P3/04;A61P3/06;A61P3/10;A61P5/00;A61P9/00;A61P9/10;A61P9/12;A61P15/00;A61P19/10;A61P25/00;A61P25/22;A61P25/24;A61P25/28;A61P35/00;C07D265/10;C07D413/10;C07D417/10;C07D471/04;C07D473/12 |
主分类号 |
A61K31/5355 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|