| 摘要 |
A microfluidic device for detecting target molecules in a fluid, the microfluidic device having a hybridization chamber containing electrodes and probes for hybridization with target molecules to form probe-target complexes and generate an electrochemiluminescence (ECL) signal in response to an electrical current between the electrodes, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the hybridization chamber has a floor surface positioned parallel to the active area of the photodiode, the floor surface having a centroid and the active area being encompassed within a cone having the centroid at its vertex, and a vertex angle less than 174°.
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