发明名称 |
METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
摘要 |
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
|
申请公布号 |
US2011311549(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
US201113083441 |
申请日期 |
2011.04.08 |
申请人 |
SCHWAEBLE HANS-WILHELM;TEDFORD CLARK E.;PARENT JAMES B.;DUDLER THOMAS;DEMOPULOS GREGORY A.;LEICESTER, UNIVERSITY OF;OMEROS CORPORATION |
发明人 |
SCHWAEBLE HANS-WILHELM;TEDFORD CLARK E.;PARENT JAMES B.;DUDLER THOMAS;DEMOPULOS GREGORY A. |
分类号 |
A61K39/395;A61P7/00;A61P7/04;A61P7/06;A61P11/00;A61P27/02;A61P29/00 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|