VACCINES COMPRISING ADENOVIRUS VECTORS AND SIGNALING LYMPHOCYTE ACTIVATING MOLECULE-ASSOCIATED PROTEIN (SAP)

摘要

The invention provides replication incompetent adenovirus vectors containing a heterologous nucleic acid sequence that encodes at least a portion of a SLAM family receptor adaptor protein (SAP), and optionally further encodes a polypeptide of interest. The compositions and methods are useful for enhancing a subject's immune response to a polypeptide of interest by expression, in one or more vectors, of the polypeptide of interest and a SLAM family receptor adaptor protein. Furthermore, the compositions and methods are also useful for induction of an innate immune response and/or an adaptive cellular and/or humoral immune response for vaccination applications.