摘要 |
<p>Disclosed is a sustained-release composition in which a physiologically active substance comprised of a water soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, wherein the physiologically active substance is contained in an amount of 15 to 35 (weight/weight)% to the total microcapsule, the weight average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, and the physiologically active substance is a peptide of formula: 5-oxo-Pro-His-Trp-Ser-Tyr-Y-Leu-Arg-Pro-Z wherein, Y represents DLeu, DAla, DTrp, DSer (tBu), D2Nal or DHis (ImBzl) and Z represents NH-C2H5 or Gly-NH2, or a salt thereof; and the sustained-release composition further contains stearic acid.</p> |