发明名称 |
NEW CATHEPSIN S PROTEASE INHIBITORS, USEFUL IN THE TREATMENT OF E.G. AUTOIMMUNE DISORDERS, ALLERGY AND CHRONIC PAIN CONDITIONS |
摘要 |
<p>Compounds of the formula (I) wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents; or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1- C6dialkylamino or; R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents; n is 1, 2 or 3; for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.</p> |
申请公布号 |
WO2011158197(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011IB52613 |
申请日期 |
2011.06.16 |
申请人 |
MEDIVIR UK LIMITED;AYESA, SUSANA;GRABOWSKA, URSZULA;HEWITT, ELLEN;JOENSSON, DANIEL;KLASSON, BJOERN;KAHNBERG, PIA;LUNDGREN, STINA;TEJBRANT, JAN;WIKTELIUS, DANIEL |
发明人 |
AYESA, SUSANA;GRABOWSKA, URSZULA;HEWITT, ELLEN;JOENSSON, DANIEL;KLASSON, BJOERN;KAHNBERG, PIA;LUNDGREN, STINA;TEJBRANT, JAN;WIKTELIUS, DANIEL |
分类号 |
C07C237/14;A61K31/16;A61P11/00;A61P37/00;C07D233/58 |
主分类号 |
C07C237/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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