Pyridine derivatives as inhibitors of protein tyrosine kinase activity

摘要

Discloses is are the compounds (as depicted): 1-cyclopropyl-3-(3-fluoro-4-(2-(5-((2-oxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b ]pyridin-7 -yloxy)phenyl) urea; 1-(4-(2-(5-5,8,11, 14-Tetraoxa-2-azapentadecylpyridin-2-yl)thieno[3,2-b ]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea; N-(3-Fluoro-4-(2-( 5-( (2-methoxyethylamino )methyl)pyridin-2-yl)thieno [3 ,2-b ]pyridin-7-yloxy)phenyl)cyclopropanecarboxamide; 4-(3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)- 1-methyl-1H-imidazol-2-yl)thieno[3,2-b ]pyridin-7-yloxy )phenyl )ureido )benzamide; 3-(3-(3-fluoro-4-(2-(5-((2-methoxyethylamino )methyl )pyridin-2-yl)thieno [3,2-b ]pyridin-7-yloxy)phenyl)ureido )benzoic acid; cyclopentyl 3-fluoro-4-(2-(5-((2-methoxyethylarnino)methyl)pyridin-2-yl)thieno[3,2- b ]pyridin-7 -yloxy)phenylcarbamate; 1-cyclopropyl-3-(3-fluoro-4-(2-(5-(1',1'-dioxothiomorpholinomethyl)pyridin-2- yl)thieno[3,2-b ]pyridin-7-yloxy)phenyl)urea; and 1-cyclopropyI-3-(3-fluoro-4-(2-(5-( (2-oxooxazolidin-3-yl)methyl)pyridin-2-yI)thieno[3 ,2-b ]pyridin-7 -yloxy)phenyl)urea. Also disclosed is a composition comprising a compound as listed, the use of a compound as listed in the preparation of a medicament for treating ophthalmic disease and the method of treating a non-human for ophthalmic disease with a compound as listed.