摘要 |
Disclosed is a block copolymer for a drug conjugate, said copolymer comprising a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain, wherein the block copolymer comprises the structure of formula (I) or (II) wherein R1, which may be the same or different, represents a hydrogen atom, a methoxy group, a methyl group, or a substituted linear or branched or cyclic C1-C12 alkyl group, in which the substituent represents a functional group selected from the group consisting of a maleimide group, an amino group, a carboxyl group, a thiol group, a hydroxy group and an active ester group which may be protected, R2 represents a hydrogen atom, a saturated or an unsaturated C1-C30 aliphatic carbonyl group or an arylcarbonyl group, R3 represents -O-R5 or -NH-R5 in which R5, which may be the same or different, represents a hydrophobic group, and R4 represents a hydroxy group, a saturated or an unsaturated C1-C30 aliphatic oxy group or an aryl-lower alkyloxy group, L1 and L2 independently from each other represents a linker, m represents an integer of 5-1000, n represents an integer of 0-1000, p represents an integer of 1-1000, and q represents an integer of 1-1000, provided that when units having a hydrophobic group in the side chain account for 20% or more to less than 90% of the total units of the polyamino acids in the block copolymer and units having a carboxylic acid group in the side chain are present, then the units having a carboxylic acid group in the side chain, units having a hydrophobic group in the side chain, and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and when units having a carboxylic acid group in the side chain are absent, then units having a hydrophobic group in the side chain and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and y represents an integer of 1 or 2.
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