| 摘要 |
A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.
|
