发明名称 |
AN EXTENDED-RELEASE COMPOSITION COMPRISING A SOMATOSTATIN DERIVATIVE IN MICROPARTICLES |
摘要 |
Disclosed is a pharmaceutical composition for extended release comprising microparticles with a polymer matrix comprising a linear and a branched polyactide-co-glycolide polymer and pasireotide pamoate as active ingredient, wherein the microparticles are produced by suspending pasireotide pamoate in a polymer solution, wherein said polymer solution comprises methylene chloride and a polymer mixture of said linear and branched polyactide-co-glycolide polymer, wherein the concentration of the polymer mixture in methylene chloride is between 14.24% and 17.45% (weight polymer per weight polymer solution). |
申请公布号 |
NZ580589(A) |
申请公布日期 |
2011.12.22 |
申请号 |
NZ20080580589 |
申请日期 |
2008.05.23 |
申请人 |
NOVARTIS AG |
发明人 |
LAMBERT, OLIVIER;RIEMENSCHNITTER, MARC;VUCENOVIC, VITOMIR |
分类号 |
A61K9/50;A61K38/00 |
主分类号 |
A61K9/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|