| 发明名称 |
Chemokine receptor antagonists and methods of use thereof |
| 摘要 |
Disclosed herein is a pyrrolidine compound as given, wherein n is an integer from 1 to 4, M is CR1R2, q1 is 0, q2 is 1, and the other substituents are as defined within the specification. Also disclosed are processes for their preparation, compositions comprising said compounds and use of the compounds in the treatment of a disease associated with aberrant leukocyte recruitment, activation or recruitment and activation. |
| 申请公布号 |
NZ585746(A) |
申请公布日期 |
2011.12.22 |
| 申请号 |
NZ20020585746 |
申请日期 |
2002.11.13 |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
LULY, JAY R;NAKASATO, YOSHISUKE;HARRIMAN, GERALDINE C B;CARSON, KENNETH G;OHSHIMA, ETZUO;GHOSH, SHOMIR;ELDER, AMY M;MATTIA, KAREN M |
| 分类号 |
C07D491/044;C07D519/00;A61K;A61K31/4353;A61K31/438;A61K31/4427;A61K31/451;A61K31/4523;A61K31/4525;A61K31/4535;A61K31/4545;A61K31/496;A61K31/506;A61K31/527;A61K31/537;A61K31/5377;A61K31/55;A61K31/5513;A61P;A61P1/00;A61P1/04;A61P3/10;A61P9/00;A61P9/10;A61P11/06;A61P13/12;A61P19/02;A61P25/28;A61P29/00;A61P31/18;A61P37/02;A61P37/08;A61P43/00;C07D;C07D211/52;C07D221/00;C07D223/00;C07D223/20;C07D313/00;C07D313/12;C07D337/00;C07D337/12;C07D401/06;C07D401/14;C07D405/00;C07D405/06;C07D409/06;C07D451/00;C07D471/04;C07D491/00;C07D491/04;C07D493/04;C07D495/04;C07D497/04;C07D513/04 |
主分类号 |
C07D491/044 |
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