| 摘要 |
Disclosed is a compound having the formula (I) e.g. 1-(4-Cyano-3-trifluoromethyl-phenyl)-3-[7-(4-cyano-3-trifluoromethyl-phenyl)]-6-thioxo-5-tolyl-5,7-diaza-spiro[3.4]oct-8-ylidene) thiourea wherein R1 and R2 are, together with the carbon to which they are linked, a cycloalkyl group, wherein R3 is selected from the group consisting of dialkylcarbamoylalkyl, and cyanoalkyl, and wherein R4 is hydrogen or fluorine for the treatment of a hyperproliferative disorder. Also disclosed is a method of synthesizing a diaryl compound of formula (I) comprising mixing 4-Isothiocyanato-2-trifluoromethylbenzonitrile with N-Methyl 2-fluoro-4-(1-cyanocyclopentyl)aminobenzamide in a first polar solvent to form a mixture, heating the mixture, adding a second polar solvent, the same as or different from the first polar solvent, and an aqueous acid to the mixture, refluxing the mixture, cooling the mixture and combining with water, and separating the compound from the mixture.
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